DYSBIOSIS 101: the impact of antibiotics, FODMAPs, & TMAO

DYSBIOSIS 101: the impact of antibiotics, FODMAPs, & TMAO

WHAT IS DYSBIOSIS?

Dysbiosis describes imbalance in the gut microbiome, with:

A COMPLEX ECOSYSTEM

The gut microbiome is like any other ecosystem, with delicate balance between all organisms.

A seemingly small disruption (like a few days of antibiotics) can have ripple effects on the entire

ecosystem for years to come.

A healthy microbiome means minimal bloating & gas, minimal food sensitivities, consistent energy and mental clarity, clear skin, and regularity (at least 1 formed BM every day).

DYSBIOSIS 101: the impact of antibiotics, FODMAPs, & TMAO

CONTRIBUTING FACTORS TO DYSBIOSIS

CONTRIBUTING FACTORS TO DYSBIOSIS

What about FODMAPs?

While high-FODMAP foods may exacerbate symptoms of dysbiosis, they are not a root cause of imbalance.

FODMAP carbs are very prebiotic, so bloating is indication that your microbiome is adjusting.

Most people can improve FODMAP sensitivity by diversifying their diet and slowly increasing FODMAP intake.


3 WAYS TO IMPROVE DYSBIOSIS

DYSBIOSIS 101: the impact of antibiotics, FODMAPs, & TMAO

address the issue

if dysbiosis is driven by one or more of these factors, minimize to the extent you can

prioritize plants

feed beneficial species with a diversity of colorful, fibrous plant foods in every meal

minimize processed foods

refined sugar, processed oils, and fried foods feed opportunistic microbes

What about animal products?

When you consume red meat, eggs, and full-fat dairy, certain gut microbes produce the metabolite TMAO.

TMAO has been linked to cardiovascular issues, hence "heart healthy" recommendations to limit animal products.

However, completely removing these foods from your diet removes important bioavailable nutrient sources.

Rather, consider the QUALITY, PREPARATION, and CONTEXT.

A greasy burger and fries is going to have a different impact than roast beef slow-cooked with vegetables.

Animal products can have a place in a balanced diet when sourced well, prepared with gentle cooking methods, and paired with an abundance of colorful, fibrous plant foods.


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References

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Gaby, A. R. (2017). Nutritional Medicine (2nd ed.). Fritz Perlberg Publishing.Mailing, L. The Ultimate Quick Start Guide to the Microbiome. Retreived from: https://www.lucymailing.com/the-ultimate-quick-start-guide-to-the-gut-microbiome/

Molinero, N., Ruiz, L., Sánchez, B., Margolles, A., & Delgado, S. (2019). Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology. Frontiers in physiology, 10, 185. https://doi.org/10.3389/fphys.2019.00185

McDonald, D., Hyde, E., Debelius, J. W., Morton, J. T., Gonzalez, A., Ackermann, G., Aksenov, A. A., Behsaz, B., Brennan, C., Chen, Y., DeRight Goldasich, L., Dorrestein, P. C., Dunn, R. R., Fahimipour, A. K., Gaffney, J., Gilbert, J. A., Gogul, G., Green, J. L., Hugenholtz, P., Humphrey, G., … Knight, R. (2018). American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems, 3(3), e00031-18. https://doi.org/10.1128/mSystems.00031-18 Retrieved from: https://pubmed.ncbi.nlm.nih.gov/29795809/

Brinkworth GD, Noakes M, Clifton PM, Bird AR. Comparative effects of very low carbohydrate, high fat and high carbohydrate, low fat weight loss diets on bowel habit and faecal short chain fatty acids and bacterial populations. Br J Nutr . 2009;101(10):1493 502.

Hamer , H. M., D. Jonkers , et al. (2008). "Review article: the role of butyrate on colonic function." Aliment Pharmacol Ther 27 (2): 104 119.

Hawrelak, J., & Harnett, J. (2020). The Microbiome. In Advanced Clinical Naturopathic Medicine (1st ed., pp. 110–144). Elsevier.

Hawrelak, J. A., & Myers, S. P. (2004). The Causes of Intestinal Dysbiosis: A Review. Alternative Medicine Review, 9(2), 180–197.

Velasquez, M. T., Ramezani, A., Manal, A., & Raj, D. S. (2016). Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins, 8(11), 326. https://doi.org/10.3390/toxins8110326Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006). Colonic health: fermentation and short chain fatty acids. Journal of Clinical Gastroenterology, 40(3), 235–243. https://doi-org.uws.idm.oclc.org/10.1097/00004836-200603000-00014

Hill, P., Muir, J. G., & Gibson, P. R. (2017). Controversies and Recent Developments of the Low-FODMAP Diet. Gastroenterology & Hepatology, 13(1), 36–45.

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