A Functional Nutrition Approach to Helicobacter pylori
WHAT IS H PYLORI?
Helicobacter pylori is a type of bacteria that lives in the lining of the stomach.
When the body is stressed, it can grow out of control and trigger an immune attack, leading to inflammation and tissue damage.
In serious cases, an H pylori infection contributes to iron-deficiency anemia, ulcers, and stomach cancer.
IS H PYLORI NORMAL?
H pylori is found in over half the world population but is asymptomatic in most individuals.
It is believed that humans and H pylori evolved together: we provide a place for it to live and it helps "train" our immune system in return.
In that sense, it is "normal".
BUT I THOUGHT IT CAUSED ULCERS...
While this bacteria is necessary for the development of ulcers and stomach cancer, it is not sufficient (otherwise over half the world would have these conditions).
Stress, diet, medication use, strain & host genetics, and overall gut health impact whether or not H pylori becomes pathogenic.
SHOULD H PYLORI BE TREATED?
IF SERIOUS: When H pylori is found in a serious infection, it must be treated.
This typically involves a combination of acid blockers and antibiotics, but herbal antimicrobials are sometimes used (which decreases risk of it developing antibiotic resistance).
IF ASYMPTOMATIC: If H pylori is found in an asymptomatic individual, preventative treatment may or may not be necessary.
If someone has a personal or family history of ulcers or stomach cancer, then eradication is recommended.
On the other hand, the presence of H pylori may actually be protective against autoimmunity, asthma, allergies, and esophageal conditions like GERD.
NUTRITIONAL SUPPORT
DECREASE H PYLORI
antimicrobial herbals
green tea
dark grapes & berries (cranberry, elderberry, blueberry)
black cumin
broccoli sprouts
vitamin C + E
zinc carnosine
Lactobacillus probiotics
SUPPORT ULCER HEALING
cabbage juice
melatonin
L-tryptophan
mastic gum
licorice
IMPROVE TREATMENT EFFICACY
N-acetyl-cysteine (disrupts mucus layer)
Are you a health educator that wants to use this content with your clients? Customize the handout template in less time than it would take to even think about hiring a graphic designer.
References
Abe, Y., et al., The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with Barrett's esophagus in Japan. Am J Gastroenterol , 2004. 99 (7): p. 1213 21.
Bravo, D., Hoare, A., Soto, C., Valenzuela, M. A., & Quest, A. F. (2018). Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World journal of gastroenterology, 24(28), 3071–3089.
Brown, J. C., Huang, G., Haley Zitlin , V. & Jiang, X. 2008. Antibacterial effects of grape extracts on Helicobacter pylori. Appl. Environ. Microbiol AEM.01595 08.
Celinski, K., P. C. Konturek , et al. (2011). "Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans." J Physiol Pharmacol 62 (5): 521 526.
Chatterjee, A., Yasmin , T., Bagchi , D. & Stohs , S. J. 2004. Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin . Molecular and Cellular Biochemistry, 265 19 26.
Cheney, G. (1949). "Rapid healing of peptic ulcers in patients receiving fresh cabbage juice." Calif Med 70 (1): 10 15.
de Brito, B. B., da Silva, F., Soares, A. S., Pereira, V. A., Santos, M., Sampaio, M. M., Neves, P., & de Melo, F. F. (2019). Pathogenesis and clinical management of Helicobacter pylori gastric infection. World journal of gastroenterology, 25(37), 5578–5589.
Diaconu, S., Predescu, A., Moldoveanu, A., Pop, C. S., & Fierbințeanu-Braticevici, C. (2017). Helicobacter pylori infection: old and new. Journal of medicine and life, 10(2), 112–117.
Eurogast. (993). "Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group." Gut 34 (12): 1672 1676
Everson, M., Boshoven, A. M., & Last, A. (2022). A guide to GERD, H pylori infection, and Barrett esophagus. The Journal of Family Practice, 71(5), E1–E7. https://doi-org.uws.idm.oclc.org/10.12788/jfp.0428
Fontes, L. E. S., Martimbianco, A. L. C., Zanin, C., Riera, R., & Fontes, L. E. S. (n.d.). N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication. Cochrane Database of Systematic Reviews, 2.
Galan, M. V., Kishan , A. A. & Silverman, A. L. 2004. Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. Dig Dis Sci 49 1088 90. PMID 15387326
Graham, D. Y. & Fischbach , L. 2010. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut, 59 1143 1153.
Gurbuz AK, Ozel Am, Ramazan O, et al. Effect of n acetyl cysteine on Helicobacter pylori. (2005). Southern Medical Journal. 98(11):1095 1097.
Helicobacter Pylori. John Hopkins Medicine. Retrieved from https://www.hopkinsmedicine.org/health/conditions-and-diseases/helicobacter-pylori
Hung, I. F. and B. C. Wong (2009). "Assessing the risks and benefits of treating Helicobacter pylori infection." Therap Adv Gastroenterol 2 (3): 141 147.
Kusters, J. G., van Vliet, A. H., & Kuipers, E. J. (2006). Pathogenesis of Helicobacter pylori infection. Clinical microbiology reviews, 19(3), 449–490. https://doi.org/10.1128/CMR.00054-05
Lee, J. H., Shim, J. S., Chung, M. S., Lim, S. T. & Kim, K. H. 2009. In vitro anti adhesive activity of green tea extract against pathogen adhesion. Phytother Res, 23 460 6. PMID 19107860
Matsushima, M., Suzuki, T., Masui, A., Kasai, K., Kouchi , T., Takagi, A., Shirai , T. & Mine, T. 2008. Growth inhibitory action of cranberry on Helicobacter pylori. J Gastroenterol Hepatol 23 Suppl 2 S175 80. PMID 19120894
Mahady, G. B., Pendland , S. L., Stoia , A., Hamill , F. A., Fabricant, D., Dietz, B. M. & Chadwick, L. R. 2005. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res, 19 988 91. PMID 16317658
Mukaisho, K., Hagiwara, T., Nakayama, T., Hattori, T., & Sugihara, H. (2014). Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD. World journal of gastroenterology, 20(34), 11962–11965. https://doi.org/10.3748/wjg.v20.i34.11962\
Parikh NS, Ahlawat R. Helicobacter Pylori. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534233/
Pereira Lima, J.C., et al., The role of cagA Helicobacter pylori strains in gastro oesophageal reflux disease. Eur J Gastroenterol Hepatol , 2004. 16 (7): p. 643 7.
Saggioro, A., Caroli , M., Pasini , M. & Al, E. 2005. Helicobacter pylori eradication with Lactobacillus reuteri. A double blind placebo controlled trial. Dig Liver Dis 37S S88.
Salem, E. M., Yar , T., Bamosa , A. O., Al Quorain , A., Yasawy , M. I., Alsulaiman , R. M. & Randhawa , M. A. 2010. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non ulcer dyspepsia. Saudi J Gastroenterol 16 207 14. PMID 20616418
Sezikli, M., Z. A. Çetinkaya , et al. (2011). "Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity." Clinics and Research in Hepatology and Gastroenterology 35 (11): 745 749.
Sezikli, M., Z. A. Cetinkaya , et al. (2012). "Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori." J Clin Pharm Ther 37 (3): 282 285.
Sipponen, P., Hyvärinen, H., & Siurala, M. (1996). H. pylori corpus gastritis--relation to acid output. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 47(1), 151–159.
Zhang, L., Ma, J., Pan, K., Go, V. L. W., Chen, J. & You, W. C. 2005. Efficacy of Cranberry Juice on Helicobacter pylori Infection: a Double Blind, Randomized Placebo Controlled Trial. Helicobacter, 10 139 145. PMID